F. Boel, M.A. van den Berg, N.S. Riedstra, M.M.A. van Buuren, J. Tang, H. Ahedi, N. Arden, S.M.A.Bierma-Zeinstra, C.G. Boer, F.M. Cicuttini, T.F. Cootes, K.M. Crossley, D.T. Felson, W.P. Gielis, J.J. Heerey, G. Jones, S. Kluzek, N.E. Lane, C. Lindner, J.A. Lynch, J.B.J. van Meurs, A. Mosler, A.E. Nelson, M.C. Nevitt, E.H. Oei, H. Weinans, J. Runhaar, R. Agricola
Hip morphology has been recognized as an important risk factor for the development of hip OA. In previous studies within the Worldwide Collaboration on OsteoArthritis prediCtion for the Hip consortium(World COACH), both acetabular dysplasia (AD) and pincer morphology–characterized by acetabular under- and overcoverage of the femoral head–were associated with the development of radiographic hip OA (RHOA) within 4-8 years, with an oddsratio (OR) of 1.80 (95% confidence interval (CI) 1.40-2.34) and 1.50 (95% CI1.05-2.15), respectively. However, we know that not everyone with AD or pincer morphology will develop RHOA. Specific baseline characteristics or variations in hip shape among individuals with AD and pincer morphology may influence their risk of developing RHOA. Statistical shape models (SSM), describing the mean hip shape of a population and a range of independent shape variations, can be utilized to study these variations in hip shape.
To evaluate whether specific hip shape variations or baseline characteristics within individuals with either AD or pincer morphology are associated with the development of RHOA within 4-8 years.
We pooled individual participant data from seven prospective cohort studies within the World COACH consortium. Standardized anteroposterior (AP) pelvic radiographs were obtained at baseline and within4-8 years follow-up. RHOA was scored by KLG or (modified) Croft grade. We harmonized the RHOA scores into “No OA” (KLG/Croft = 0), “doubtful OA” (KLG/Croft= 1), or “definite OA” (KLG/Croft ≥ 2 or total hip replacement). The Wiberg center edge angle (WCEA), measuring the weight-bearing femoral head coverage, and the lateral center edge angle (LCEA), measuring the bony femoral head coverage, were automatically determined using a validated method. Hips were included if they had baseline and follow-up RHOA scores, no RHOA at baseline, and either AD defined by a WCEA ≤ 25° or pincer morphology defined by a LCEA≥45°. For both populations, an SSM was created of the acetabular roof, posterior wall, femoral head and neck, and teardrop (Fig 1). We analyzed the first 13 shape modes that explained around 90% of total shape variation in the population. The association between each shape mode, sex, baseline age, BMI, diabetes and smoking habits, and the development of RHOA was estimated using univariate generalized linear mixed-effects models. The mixed effects were added to account for the potential clustering within cohorts and participants. The results were expressed as ORs with 95% CIs.
The AD population consisted of 4,737 hips, of which 2.6% developed incident RHOA (Table 1). Four of the 13 shape modes (Fig 1) were associated with the development of RHOA. Additionally, in hips with AD, females had higher odds of incident RHOA than males (OR 2.85, 95% CI 1.46 – 5.58), and each year increase in baseline age was associated with higher odds of incident RHOA (OR 1.05, 95% CI 1.02 – 1.09). Neither baseline BMI, diabetes, nor smoking habits were associated with RHOA within people with AD. The pincer morphology population comprised 1,118 hips, of which 2.8% developed incident RHOA. Only one of the shape modes was associated with incident RHOA (Fig 1). Sex, baseline age, BMI, diabetes, and smoking habits were not associated with RHOA within people with pincer morphology.
Variations in shape among individuals with AD and pincer morphology contribute to the odds of developing RHOA. In individuals with AD, both sex and baseline age were also associated with RHOA development. However, this was not observed in those with pincer morphology. These findings may inform the development of personalized risk assessment tools and preventative strategies for hip OA.
Published: https://doi.org/10.1016/j.ostima.2025.100341
