About hip osteoarthritis

Over 500 million people are affected by OA worldwide, leading to a global prevalence of around 7%. The forecast for OA is alarming; with an ageing population the prevalence is expected to rise dramatically in the coming decades.
OA can affect any joint and is most prevalent in the knee and hip, with hip OA leading to the greatest disability

Despite its tremendous burden, there is no curable treatment available and current strategies therefore focus on symptomatic treatment, with only modest effect. This is mainly due to a lack of knowledge on the etiology, pathophysiology and risk factors of hip OA. Still, some risk factors for hip OA have previously been identified on a group level such as age, gender, genetics, race and hip morphology. However, current cohort studies are underpowered to detect risk factors and predict the risk of hip OA on an individual level. The lack of knowledge on person specific risk factors for hip OA makes efficient and effective preventive and treatment strategies challenging, if not impossible.

About the consortium

We want to change the current ‘one size fits all’ management into person specific preventive and treatment strategies. This all starts with better knowledge on determinants and risk factors for hip OA. However, a lot of data is needed to create such personalized predictions for hip OA.

This is why we initiated the Worldwide Collaboration in OsteoArthritis prediCtion of the Hip: the World COACH consortium. This consortium  includes all prospective cohort studies worldwide that have longitudinal (with at least 4 years apart) hip imaging data available (Figure 1).

Our aims are to better understand determinants and risk factors for development and progression of hip OA and to develop a person specific risk prediction model for hip OA.
With this knowledge, we hope to guide future person specific prevention and treatment strategies.


Work packages

To study the research questions of the World COACH consortium, we created several work packages:

The team

Dr Rintje Agricola
Chair & Executive coordinator
Dr Stefan Kluzek
Steering Committee Member
Prof Sita Bierma-Zeinstra
Steering Committee Member
Prof Graeme Jones
Steering Committee Member
Dr Claudia Lindner
Steering Committee Member
Prof Joyce van Meurs
Steering Committee Member
Prof Kay Crossley
Steering Committee Member (FORCe)
Dr Amanda Nelson
Steering Committee Member
Prof Michael Nevitt
Steering Committee Member
Prof Harrie Weinans
Steering Committee Member
Prof David Felson
Advisory Committee member
Prof Nancy Lane
Advisory Committee member
Prof Tim Spector
Advisory Committee member
Myrthe van den Berg
PhD candidate
Michiel van Buuren
PhD candidate
Fleur Boel
PhD candidate
Jinchi Tang
PhD candidate
Noor Riedstra
PhD candidate
Julie Herfkens
PhD candidate
Dr Vahid Arbabi
Affiliated Investigator (methods)
Prof Flavia Cicuttini
Affiliated Investigator (TASOAC cohort)
Prof Timothy Cootes
Affiliated Investigator (image analysis)
Dr John Lynch
Affiliated Investigator (MOST, OAI)
Dr Andrea Mosler
Affiliated Investigator (FORCe)
Dr Edwin Oei
Affiliated Investigator (Musculoskeletal radiologist, CHECK cohort, Rotterdam study)
Dr Joshua Heerey
Affiliated Investigator (FORCe)
Dr Jos Runhaar
Affiliated Investigator (CHECK cohort, Rotterdam study)

Publications

all publications

Contact

Collaborate?

Do you want to collaborate with the World COACH consortium? Do you have a research proposal for using the consortium database? Contact us!

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